aurora-a kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9040	Aurora kinase inhibitor-2	IUN-70219,Aurora Kinase Inhibitor II	Aurora Kinase
	Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).		Aurora Kinase
T6767	TCS7010	Aurora A Inhibitor I	Apoptosis , Aurora Kinase
	TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.		Apoptosis , Aurora Kinase
T21981	Phthalazinone pyrazole		Aurora Kinase
	Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.		Aurora Kinase
T23426	TC-A 2317 hydrochloride		Others , Aurora Kinase
	TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.		Others , Aurora Kinase
T8537	Tripolin A		Aurora Kinase
	Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)		Aurora Kinase
T5524	Aurora kinase inhibitor-3	Aurora Kinase Inhibitor III	Aurora Kinase
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.		Aurora Kinase
T11638	Ilorasertib hydrochloride	ABT-348 hydrochloride	Aurora Kinase
	Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase,...		Aurora Kinase
T6126	JNJ-7706621	JNJ 7706621	Apoptosis , CDK , Aurora Kinase
	JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.		Apoptosis , CDK , Aurora Kinase
TQ0059	Ilorasertib	ABT-348	VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
	Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...		VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
T2509	Tozasertib	MK-0457,VX 680	Aurora Kinase , Autophagy
	Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases.		Aurora Kinase , Autophagy
T6068	MK-5108	VX-689,MK5108	Aurora Kinase , Autophagy
	MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.		Aurora Kinase , Autophagy
T50110	CD532		Aurora Kinase
	CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational tran...		Aurora Kinase
T1825	Reversine		Aurora Kinase , Adenosine Receptor , Autophagy
	Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).		Aurora Kinase , Adenosine Receptor , Autophagy
T2611	CCT 137690	CCT137690	Apoptosis , Aurora Kinase
	CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).		Apoptosis , Aurora Kinase
T2358	ENMD-2076		Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T17267	XL228		IGF-1R , Bcr-Abl , Src , Aurora Kinase
	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).		IGF-1R , Bcr-Abl , Src , Aurora Kinase
T6315	MLN8054		Casein Kinase , PKA , Src , Aurora Kinase
	MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.		Casein Kinase , PKA , Src , Aurora Kinase
T34888	TL12-186	TL12 186,TL12186	CDK , Ligand for E3 Ligase
	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.		CDK , Ligand for E3 Ligase
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
T22288	(1E)-CFI-400437 dihydrochloride	CFI-400437 dihydrochloride	PLK
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.		PLK